Effects of a nitric oxide scavenger, carboxy-PTIO, on isoflurane MAC and cerebellar nitric oxide synthase activity in rats

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Effects of a nitric oxide scavenger, carboxy-PTIO, on isoflurane MAC and cerebellar nitric oxide synthase activity in rats.

Recent studies have indicated that nitric oxide may play a role in inhalation anaesthesia. Inhibition of nitric oxide synthase reduces the minimum alveolar concentration (MAC) for inhalation anaesthetics and decreases cerebellar nitric oxide synthase (NOS) activity in rats. In this study, we have explored further the role of nitric oxide in isoflurane anaesthesia by examining the effects of a n...

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The long-term potentiation (LTP), an activity-induced increase in the efficacy of neurotransmission, has long been conceived to be a physiological correlate of learning and memory. Investigations of synaptic transmission suggest that the postsynaptic N-methyl-D-aspartate (NMDA) receptor is the upstream mediator of LTP, while nitric oxide (NO), a retrograde messenger from postsynaptic neurons to...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1999

ISSN: 0007-0912

DOI: 10.1093/bja/83.6.948